"Since starting Ampyra, I have the confidence in my ability to do simple things, like keeping up? to meet friends" -Kristie

What to Expect

Multiple sclerosis (MS) may affect your walking. The good news is so might AMPYRA

AMPYRA® (dalfampridine), an oral medication, is the only treatment shown to improve walking in people with MS. This was demonstrated by an increase in walking speed. AMPYRA improved walking in significantly more people with MS than placebo (sugar pill) in two clinical trials (34.8% vs. 8.3% and 42.9% vs. 9.3%). Improving your walking may help with even the simplest things, like keeping up with friends and family. Not everyone responds to AMPYRA. Individual results may vary.

Why walking better may matter

People who walked faster in the AMPYRA clinical trials, regardless of whether they were taking AMPYRA or placebo, also reported improvements in their walking-related activities. These improvements were based on the 12-Item Multiple Sclerosis Walking Scale (or MSWS-12).

The MSWS-12 is a self-assessment tool used by patients to rate the impact of MS on their walking. It includes the following 12 areas:
  • Standing
  • Maintaining balance
  • Ability to run
  • Climbing stairs
  • Need for support
  • Walking distances
  • Moving around the home
  • Effort needed to walk
  • Concentration needed to walk
  • Ability to walk
  • Walking speed
  • Gait

How soon might you notice a change in your walking?

Some people experience improvement in their walking ability within a couple of weeks. Others notice improvement up to 6 weeks after starting.

Not everyone responds to AMPYRA. Individual results may vary. It is important to take AMPYRA as prescribed by your doctor.

Can AMPYRA cause side effects?

Do not take AMPYRA if you have ever had a seizure or have certain types of kidney problems, or are allergic to dalfampridine (4-aminopyridine), the active ingredient in AMPYRA. You could have a seizure even if you never had a seizure before. Your chance of having a seizure is higher if you take too much AMPYRA or if your kidneys have a mild decrease of function, which is common after age 50.

AMPYRA may cause serious side effects, including kidney or bladder infections, and serious allergic reactions. Stop taking AMPYRA and call your doctor right away or get emergency medical help if you have shortness of breath or trouble breathing, swelling of your throat or tongue, or hives. The most common adverse events for AMPYRA in MS patients were urinary tract infection, trouble sleeping, dizziness, headache, nausea, weakness, back pain, and problems with balance.

For more information, please see the complete Medication Guide.

AMPYRA® (dalfampridine) is indicated as a treatment to improve walking in patients with multiple sclerosis (MS). This was demonstrated by an increase in walking speed.

IMPORTANT SAFETY INFORMATION

Do not take AMPYRA if you
  • have ever had a seizure,
  • have certain types of kidney problems, or
  • are allergic to dalfampridine (4-aminopyridine), the active ingredient in AMPYRA.

Take AMPYRA exactly as prescribed by your doctor.

Before taking AMPYRA, tell your doctor if you
  • have kidney problems or any other medical conditions
  • are taking compounded 4-aminopyridine
  • are pregnant or plan to become pregnant. It is not known if AMPYRA will harm your unborn baby.
  • are breast-feeding or plan to breast-feed. It is not known if AMPYRA passes into your breast milk. You and your doctor should decide if you will take AMPYRA or breast-feed. You should not do both.
  • are taking any other medicines

Stop taking AMPYRA and call your doctor right away if you have a seizure while taking AMPYRA. You could have a seizure even if you never had a seizure before. Your chance of having a seizure is higher if you take too much AMPYRA or if your kidneys have a mild decrease of function, which is common after age 50. Your doctor may do a blood test to check how well your kidneys are working before you start AMPYRA.

AMPYRA should not be taken with other forms of 4-aminopyridine (4-AP, fampridine), since the active ingredient is the same.

AMPYRA may cause serious side effects, including
  • severe allergic reactions. Stop taking AMPYRA and call your doctor right away or get emergency medical help if you have shortness of breath or trouble breathing, swelling of your throat or tongue, or hives;
  • kidney or bladder infections.

The most common adverse events for AMPYRA in MS patients were urinary tract infection, trouble sleeping, dizziness, headache, nausea, weakness, back pain, and problems with balance.

Please see Patient Medication Guide for complete safety information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

AMPYRA®, ACORDA THERAPEUTICS® and the stylized ACORDA THERAPEUTICS® logo are registered trademarks of Acorda Therapeutics, Inc. | AMPYRA® is marketed by Acorda Therapeutics, Inc. and manufactured under license from Alkermes Pharma Ireland Limited (APIL), Ireland. | AMPYRACONNECT™ is a trademark of Acorda Therapeutics, Inc. | The stylized path logo and the stylized Acorda logo are trademarks of Acorda Therapeutics, Inc. | © 2014 Acorda Therapeutics, Inc. All rights reserved.

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