What to Expect
Multiple sclerosis (MS) may affect your walking. The good news is so might AMPYRA
AMPYRA® (dalfampridine), an oral medication, is the only treatment shown to improve walking in people with MS. AMPYRA improved walking in significantly more people with MS than placebo (sugar pill) in two clinical trials (34.8% vs. 8.3% and 42.9% vs. 9.3%). Improving your walking may help with even the simplest things, like keeping up with friends and family. Not everyone responds to AMPYRA. Individual results may vary.
Why walking better may matter
In the clinical studies, people who walked faster, regardless of treatment, also reported improvements in their walking-related activities.* This was shown using the 12-Item Multiple Sclerosis Walking Scale (or MSWS-12).
- Maintaining balance
- Ability to run
- Climbing stairs
- Need for support
- Walking distances
- Moving around the home
- Effort needed to walk
- Concentration needed to walk
- Ability to walk
- Walking speed
*A drug/placebo difference was not established for this outcome measure.
How soon might you notice a change in your walking?
Some people experience improvement in their walking ability within a couple of weeks. Others notice improvement up to 6 weeks after starting.
Not everyone responds to AMPYRA. Individual results may vary. It is important to take AMPYRA as prescribed by your doctor.
Can AMPYRA cause side effects?
Do not take AMPYRA if you have ever had a seizure or have certain types of kidney problems, or are allergic to dalfampridine (4-aminopyridine), the active ingredient in AMPYRA. You could have a seizure even if you never had a seizure before. Your chance of having a seizure is higher if you take too much AMPYRA or if your kidneys have a mild decrease of function, which is common after age 50.
AMPYRA may cause serious side effects, including kidney or bladder infections, and serious allergic reactions. Stop taking AMPYRA and call your doctor right away or get emergency medical help if you have shortness of breath or trouble breathing, swelling of your throat or tongue, or hives. The most common adverse events for AMPYRA in MS patients were urinary tract infection, trouble sleeping, dizziness, headache, nausea, weakness, back pain, and problems with balance.
For more information, please see the complete Medication Guide.