Safety and Side Effects

What is the most important information you need to know about AMPYRA?

AMPYRA^® (dalfampridine) is indicated as a treatment to improve walking in people with multiple sclerosis (MS). This was demonstrated by an increase in walking speed.

Not everyone responds to AMPYRA. Individual results may vary.

Do not take AMPYRA if you have ever had a seizure or have certain types of kidney problems, or are allergic to dalfampridine (4-aminopyridine), the active ingredient in AMPYRA . You could have a seizure even if you never had a seizure before. Your chance of having a seizure is higher if you take too much AMPYRA or if your kidneys have a mild decrease of function, which is common after age 50.

AMPYRA should not be taken with other forms of 4-aminopyridine (4-AP, fampridine), since the active ingredient is the same.

AMPYRA may cause serious side effects, including kidney or bladder infections, and serious allergic reactions . Stop taking AMPYRA and call your doctor right away or get emergency medical help if you have shortness of breath or trouble breathing, swelling of your throat or tongue, or hives . The most common adverse events for AMPYRA in MS patients were urinary tract infection, trouble sleeping, dizziness, headache, nausea, weakness, back pain, and problems with balance.

Take AMPYRA exactly as your doctor tells you to take it. Take AMPYRA tablets whole. Do not break, crush, chew or dissolve AMPYRA tablets before swallowing. If you miss a dose of AMPYRA, do not make up the missed dose. Do not take 2 doses at the same time.

Before taking AMPYRA tell your doctor if you are pregnant or plan to become pregnant. It is not known if AMPYRA will harm your unborn baby. Tell your doctor if you are breast-feeding or plan to breast-feed. It is not known if AMPYRA passes into your breast milk. You and your doctor should decide if you will take AMPYRA or breast-feed. You should not do both.

For more information, please see the complete Medication Guide.