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Your Moment of Truth About Walking and MS

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EXPERIENCED WALKING-RELATED LIMITATIONS

It can happen to anyone with MS at any time: the realization that your walking has changed. Maybe you can't keep up with family and friends. Or have trouble crossing the street in time.

If you've noticed changes in your walking, you're not alone. In a poll of more than 2,000 people with MS, 87% said they experienced some limitation to their walking ability and limited activities that involved walking.*

*According to a 2008 poll, A Patient Survey of Mobility and Exercise Issues Among MS Patients, commissioned by Acorda Therapeutics, Inc. and the Multiple Sclerosis Association of America.

Many patients experience walking difficulty

According to a survey of more than 1,000 US adults with MS, about 46% experienced walking difficulty at least twice a week. Of those who experienced walking difficulty:

  • Nearly 2 in 5 (39%) said they experienced mobility issues before they were diagnosed with MS

According to a Harris Interactive poll commissioned by Acorda Therapeutics, Inc. and the National MS Society. July 29, 2011.

Experienced walking difficulty at least twice a week

46%

Experienced mobility issues before diagnosis

39%

Changes in your walking can happen even in the early stages of MS.

Indication

AMPYRA® (dalfampridine) Extended Release Tablets, 10 mg, is the first and only brand prescription medicine indicated to help improve walking in adults with multiple sclerosis (MS). This was demonstrated by an increase in walking speed.

Important Safety Information

Do not take AMPYRA if you have ever had a seizure, have certain types of kidney problems, or are allergic to dalfampridine (4-aminopyridine), the active ingredient in AMPYRA.

Indication & Important Safety Information

INDICATION

AMPYRA® (dalfampridine) Extended Release Tablets, 10 mg, is the first and only brand prescription medicine indicated to help improve walking in adults with multiple sclerosis (MS). This was demonstrated by an increase in walking speed.

IMPORTANT SAFETY INFORMATION

Do not take AMPYRA if you:

  • have ever had a seizure,
  • have certain types of kidney problems, or
  • are allergic to dalfampridine (4-aminopyridine), the active ingredient in AMPYRA.

Take AMPYRA exactly as prescribed by your doctor.

Before taking AMPYRA, tell your doctor if you:

  • have any other medical conditions
  • are taking compounded 4-aminopyridine
  • are taking any other prescription or OTC medicines, such as cimetidine
  • are pregnant or plan to become pregnant. It is not known if AMPYRA will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if AMPYRA passes into your breast milk. Talk with your healthcare provider about the best way to feed your baby if you take AMPYRA.

Stop taking AMPYRA and call your doctor right away if you have a seizure while taking AMPYRA. You could have a seizure even if you never had a seizure before. Your chance of having a seizure is higher if you take too much AMPYRA or if your kidneys have a mild decrease of function, which is common after age 50. Your doctor may do a blood test to check how well your kidneys are working before you start AMPYRA.

AMPYRA should not be taken with other forms of 4-aminopyridine (4-AP, fampridine), since the active ingredient is the same.

AMPYRA may cause dizziness or vertigo. If you have these symptoms do not drive, operate machinery or do other dangerous activities.

AMPYRA may cause serious side effects, including severe allergic reactions. Stop taking AMPYRA and call your doctor right away or get emergency medical help if you have shortness of breath or trouble breathing, swelling of your throat or tongue, or hives.

The most common side effects for AMPYRA in MS patients were urinary tract infection; trouble sleeping; dizziness; headache; nausea; weakness; back pain; problems with balance; multiple sclerosis relapse; burning, tingling, or itching of your skin; irritation in your nose and throat; constipation; indigestion; and pain in your throat.

Please see the Patient Medication Guide.

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