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What to Expect with the Walking Pill

As you begin therapy with AMPYRA® (dalfampridine) Extended Release Tablets, 10 mg, you might be wondering what you can expect.

AMPYRA is the only prescription medicine indicated to help improve walking in adults with MS. This was demonstrated by an increase in walking speed.

AMPYRA does not work for everyone, and people experience different levels of response to the medication. Ask your doctor if AMPYRA may be right for you.

How long will it take to see improvement?

It is important to be patient with your progress. Some patients experienced improvement in their walking ability within a couple of weeks. Others noticed improvement up to 6 weeks after starting AMPYRA.

AMPYRA does not work for everyone, and people experience different levels of response to the medication. It is important to take AMPYRA as prescribed by your doctor.

People who walked faster in the AMPYRA clinical trials, regardless of whether they were taking AMPYRA or placebo (a sugar pill), also reported improvements in their walking-related activities. This was shown using the 12-item Multiple Sclerosis Walking Scale (MSWS-12), a validated, self-reported patient questionnaire rating the effect of MS on walking. In the AMPYRA clinical trials, it was used to demonstrate the clinical meaningfulness of change in walking speed.

The 12-item Multiple Sclerosis Walking Scale (MSWS-12)

  • Standing
  • Maintaining balance
  • Ability to run
  • Climbing stairs
  • Need for support outdoors
  • Walking distances
  • Need for support indoors
  • Effort needed to walk
  • Concentration needed to walk
  • Ability to walk
  • Walking speed
  • Gait

A difference between drug and placebo was not established for this outcome measure.
This is a summary of the 12 items in the MSWS-12. It is not the full questionnaire.

See how people with MS
have responded to AMPYRA

What should I tell my doctor before taking AMPYRA?

Before taking AMPYRA, tell your doctor if you

  • have kidney problems or any other medical conditions.
  • are taking compounded 4-aminopyridine.
  • are pregnant or plan to become pregnant. It is not known if AMPYRA will harm your unborn baby.
  • are breast-feeding or plan to breast-feed. It is not known if AMPYRA passes into your breast milk. You and your doctor should decide if you will take AMPYRA or breast-feed. You should not do both.
  • are taking any other medicines.

For additional Important Safety Information, please see below.

Indication

AMPYRA® (dalfampridine) Extended Release Tablets, 10 mg, is the only prescription medicine indicated to help improve walking in adults with MS. This was demonstrated by an increase in walking speed.

Important Safety Information

Do not take AMPYRA if you have ever had a seizure, have certain types of kidney problems, or are allergic to dalfampridine (4-aminopyridine), the active ingredient in AMPYRA.

Indication & Important Safety Information

AMPYRA® (dalfampridine) Extended Release Tablets, 10 mg, is the only prescription medicine indicated to help improve walking in adults with MS. This was demonstrated by an increase in walking speed.

IMPORTANT SAFETY INFORMATION

Do not take AMPYRA if you

  • have ever had a seizure,
  • have certain types of kidney problems, or
  • are allergic to dalfampridine (4-aminopyridine), the active ingredient in AMPYRA.

Take AMPYRA exactly as prescribed by your doctor.

Before taking AMPYRA, tell your doctor if you

  • have kidney problems or any other medical conditions
  • are taking compounded 4-aminopyridine
  • are pregnant or plan to become pregnant. It is not known if AMPYRA will harm your unborn baby.
  • are breast-feeding or plan to breast-feed. It is not known if AMPYRA passes into your breast milk. You and your doctor should decide if you will take AMPYRA or breast-feed. You should not do both.
  • are taking any other medicines

Stop taking AMPYRA and call your doctor right away if you have a seizure while taking AMPYRA. You could have a seizure even if you never had a seizure before. Your chance of having a seizure is higher if you take too much AMPYRA or if your kidneys have a mild decrease of function, which is common after age 50. Your doctor may do a blood test to check how well your kidneys are working before you start AMPYRA.

AMPYRA should not be taken with other forms of 4-aminopyridine (4-AP, fampridine), since the active ingredient is the same.

AMPYRA may cause serious side effects, including

  • severe allergic reactions. Stop taking AMPYRA and call your doctor right away or get emergency medical help if you have shortness of breath or trouble breathing, swelling of your throat or tongue, or hives;
  • kidney or bladder infections.

The most common adverse events for AMPYRA in MS patients were urinary tract infection, trouble sleeping, dizziness, headache, nausea, weakness, back pain, problems with balance, multiple sclerosis relapse, burning, tingling, or itching of your skin, irritation in your nose and throat, constipation, indigestion, and pain in your throat.

Please see Patient Medication Guide for additional safety information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

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